Antimicrobial peptides (AMPs) are found in a very diverse range of phyla, from bacteria to mammals, including humans . More than 2000 have already been described. In multicellular organisms they constitute primitive and conserved components of the innate immune system, functioning as a first barrier against many pathogens. Thanks to their broad spectrum of activities and targets, rapid action, and the low potential to induce resistance, AMPs have become promising prospects for new antibiotics . They kill microbes mainly by membrane targeting pore-forming mechanisms that are inherently moredifficult for microbes to circumvent by developing resistance. A significant fraction of the functionally characterized scorpion venom NDBPs displays antimicrobial activities, so they can be considered as AMPs . It is not clear why they are present in the scorpion venom. They could play a synergistic role in facilitating venom activity or be part of the antimicrobial response within the venom gland